These fibers possess unique physical characteristics, such as high surface area-volume ratio and improved mechanical strength, compared to their micro-scaled counterparts. Nanofibers produced by electrospinning represent a promising candidate scaffold biomaterial for tissue engineering ( Li et al., 2005). To meet the requirements for various tissue engineering applications, a variety of 3D scaffolds of different compositions have been developed. A 3D, highly porous substrate that mimics the native ECM can form unique spatial interactions with cells, and is thought to more accurately replicate cell-matrix interactions in vivo, compared to two-dimensional (2D) substrates commonly used for tissue culture ( Griffith and Swartz, 2006). Similarly, in vitro, cells interact intimately with and respond to cues from their matrix environment, further highlighting that cell activities are strongly influenced by the physical and chemical properties of the culture environment ( Berrier and Yamada, 2007). Biochemical and mechanical signals derived from cell-ECM interactions are critical to cell survival and functions. In a native tissue environment, cells are embedded within and are in contact with the extracellular matrix (ECM), which acts both as a structural supporter as well as a regulator of cell activities. Our product offerings include millions of PowerPoint templates, diagrams, animated 3D characters and more.Recent advances in nanotechnology and increasing recognition of the potential of nanomaterials as biocompatible and biomimetic scaffolds for cells have provided new tools for tissue engineering and the development of three-dimensional (3D) cell cultures ( Christenson et al., 2007). is brought to you by CrystalGraphics, the award-winning developer and market-leading publisher of rich-media enhancement products for presentations. Then you can share it with your target audience as well as ’s millions of monthly visitors. We’ll convert it to an HTML5 slideshow that includes all the media types you’ve already added: audio, video, music, pictures, animations and transition effects. You might even have a presentation you’d like to share with others. And, best of all, it is completely free and easy to use. Whatever your area of interest, here you’ll be able to find and view presentations you’ll love and possibly download. It has millions of presentations already uploaded and available with 1,000s more being uploaded by its users every day. is a leading presentation sharing website. Interconnected pore network for cell/tissue Three dimensional and highly porous with an.Natural biopolymers (proteins, polysaccharides).Inducing any undesirable local or systemic Optimise tissue regeneration, without elicitingĪny undesirable effects in those cells, or Mechanical signalling systems, in order to Including the facilitation of molecular and Support the appropriate cellular activity, the ability to perform as a substrate that will.The biocompatibility of a scaffold or matrix for.Signals Growth factors Drugs Mechanical forces Mechanical Failure (undergo fatigue, wear,Ĭell Source Embryonic stem cells Adult stemĮCM Metals Ceramics Synthetic polymers Natural.Can anyone guess how much all these replacements.Nerve - 200 thousand procedures per year.Liver - 200 thousand procedures per year.Kidney - 600 thousand procedures per year.Blood Vessel - 1 million procedures per year.Cartilage - 1 million procedures per year.Signaling Molecules (Growth Factors, proteins) Use of autogenous cells no rejection or pathogenĬell Culture (stem cell, osteoblast, chondrocyte,.Lost of potency in vivo for acellular polymer or.Lack of donor tissues/organs for transplantation.The life sciences towards the development ofīiological substitutes that restore, maintain, or That applies the principles of engineering and Tissue engineering is an interdisciplinary field
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